Structural Analysis of Tyrosine SpecificProtein Kinase (TPK) and Interaction Studies with Inhibitors for Lung Cancer.

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Aishwarya Hipparagi, Shambhu M G, Kusum Paul


Abstract:-The developments of drugs that inhibit target tyrosine specific protein kinase receptor (TPK) provide important insight for treatment of non-small cell lung cancer (NSCLC), as well as other cancer types. The TPK is involved in different signalling pathways within the cell function to regulate cellular proliferation from external and internal stimuli. Based on pathophysiology, the mutation of tyrosine kinase receptors may over express in cellular growth and cell proliferation that tightly trigger cellular process which mediates in developing malignancy in lungs and other internal and external organ. Our research is focusing on ROS1, ErbB2 and PTK2B of protein-protein interaction (PPI) and to regulate normal cell in to cancer and determine how these TPK pathways may lead to better therapeutic targets to developing small molecular inhibitors to control tumor growth and disease progression. We used different protein-protein interaction and signaling pathway databases to understand TRK interactions with different proteins and also integrate in structural studies of receptor tyrosine kinase might therefore provide new therapies for diseases.

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